| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303371 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2010 | 7 Pages |
Abstract
âºEndogenous H2O2 produced by Streptococcus pneumoniae inhibits FabF activity by oxidizing its active site cysteine-thiol residue. âºInhibition of FabF activity results in a significant change in membrane fatty acid composition, mainly: decreased proportions of long, unsaturated fatty acyl chains. âºThe decrease in the proportions of long, unsaturated fatty acyl chains induces the transcription of FASII genes. âºThe present study provides evidence showing that H2O2 produced by S. pneumoniae serves as a beneficial molecular signal, allowing the attenuation of FabF activity, to enable membrane adaptation at various growth conditions.
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Authors
Rachel Benisty, Aharon Yehonatan Cohen, Alexandra Feldman, Zvi Cohen, Nurith Porat,