Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8303822 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 12 Pages |
Abstract
Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways. Guest Editors: Frank Madeo and Slaven Stekovic.
Keywords
PARP1PRRBeclin-1TRAF2AMPKFLIPNLRP3DAPKFLICE-like inhibitory proteinHDGFTRADDTNFR2RIP1cIAP1TNF related apoptosis inducing ligandDRAMPCDSIRT2RIP3p53-upregulated modulator of apoptosisB-cell lymphoma extra largeAPAF1cellular inhibitor of apoptosis 1high mobility group protein B1Sirtuin 2TRAF5TaifFas associated death domaindamage-regulated autophagy modulatorCellular inhibitor of apoptosis 2TNFα receptor 1MNNGLKB1PI3KTNFαmTORFOXO1NF-kBBcl-2PTPNEMOBcl-xLTNFR1MEFsPAMPFADDHMGB1cIAP2Igf1IL1βmitochondrial outer membrane permeabilizationAIFAutophagyPermeability transition poreinterleukin 1βtumor necrosis factor alphaApoptosisapoptosis inducing factorInsulin growth factor 1apoptotic protease activating factor 1nuclear factor kappa-light-chain-enhancer of activated B cellsphosphatidyl inositol 3 kinaseFLICETRAILB-cell lymphoma 2MOMPProgrammed cell deathCell deathdeath associated protein kinasemouse embryonic fibroblastsNecroptosisNecrosismammalian target of rapamycinBcl-2 homologypathogen associated molecular patternsForkhead box protein O1receptor interacting protein 1PUMAcaspase 8liver kinase B1pathogen recognition receptor
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Authors
Vassiliki Nikoletopoulou, Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis,