Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8303823 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2013 | 31 Pages |
Abstract
The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells have developed an evolutionarily conserved adaptive mechanism, the unfolded protein response (UPR), which aims to clear unfolded proteins and restore ER homeostasis. In cases where ER stress cannot be reversed, cellular functions deteriorate, often leading to cell death. Accumulating evidence implicates ER stress-induced cellular dysfunction and cell death as major contributors to many diseases, making modulators of ER stress pathways potentially attractive targets for therapeutics discovery. Here, we summarize recent advances in understanding the diversity of molecular mechanisms that govern ER stress signaling in health and disease. This article is part of a Special Section entitled: Cell Death Pathways. Guest Editors: Frank Madeo and Slaven Stekovic.
Keywords
Retinitis pigmentosaXBP-1Drp-1NlrpAMDTXNIPHFDHSVGADD34T2DMIBDBI-1TLRUPRPKCASK1ATF6IP3RCaSRHO-1CREprotein kinase RNA (PKR)-like ER kinaseJnkATF4Jun-N-terminal kinaseinositol-requiring protein-1TAP1MEFelF2αERADNrf2ERO1αERSEBiPIRE1αER stressamyotropic lateral sclerosisBARALSDiseasesInflammatory bowel diseaseCHOPToll-like receptorType 2 diabetesHigh fat dietRIDDIntestinal epithelial cellsAgeage-related macular degenerationcytomegalovirusCMVendoplasmic reticulumeukaryotic translation initiation factorantioxidant response elementsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)activating transcription factor 4activating transcription factor 6MHCmajor histocompatibility complexmouse embryonic fibroblastCell death mechanismsAREheme oxygenase 1Hepatitis C virusHCVherpes simplex virusUnfolded protein responseBinding immunoglobulin Proteinthioredoxin-interacting proteinDynamin-related proteinProtein kinase CPERKSingle nucleotide polymorphismSNPIECBaginositol triphosphate receptorCalcium-sensing receptor
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Authors
Renata Sano, John C. Reed,