| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8303996 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 8 Pages |
Abstract
⺠Seventeen conserved lysine residues in the cytoplasmic tail of Delta like1 (Dll1) were identified and mutated. ⺠Notch signaling, ubiquitination, endocytic recycling, lipid raft localization and Notch binding functions were examined. ⺠K613 was identified as important for Notch signaling. ⺠K613R altered the multiubiquitination profile of Dll1. ⺠K613R did not alter endocytosis or stability of Dll1 but did alter binding to Notch1 and lipid raft localization.
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Authors
Liguo Zhang, Ryan C. Widau, B. Paul Herring, Patricia J. Gallagher,