Article ID Journal Published Year Pages File Type
8304020 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 7 Pages PDF
Abstract
► The α4 isoform of the sodium pump alpha subunit is expressed in Sertoli cells. ► This subunit mediates signaling cascades that are induced by ouabain. ► The ouabain-triggered Src/cRaf/Erk1/2 signaling cascade results in CREB activation. ► This cascade matches the non-classical signaling cascade induced by testosterone. ► The results may help to unveil novel mechanisms associated with male fertility.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Cardiotonic steroids trigger non-classical testosterone signaling in Sertoli cells via the α4 isoform of the sodium pump
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