Aldosterone increases VEGF-A production in human neutrophils through PI3K, ERK1/2 and p38 pathways

► Aldosterone is implicated in inflammation processes. ► Little data exist about aldosterone actions on immune cells and especially in angiogenesis. ► VEGF-A is strongly implicated in angiogenesis and synthesized by different cells notably neutrophils. ► We investigate if aldosterone was able to regulate their VEGF-A production. ► Aldosterone uses mineralocorticoid receptors, activates Pi3K, ERK1/2 and p38 pathways to increase VEGF-A production.