| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8304027 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 12 Pages |
Abstract
⺠Establishes PKCθ is expressed in pancreatic acinar cells. ⺠PKCθ is activated by stimulants of PLC or PKC, but not by those activating PKA or by pancreatic growth factors. ⺠CCK PKCθ maximal stimulation requires both high (30%) and low-affinity (70%) CCKAR state activation. ⺠PKCθ activation by CCK and TPA produces an increment in PKCθ's direct association with AKT, RafA, RafC and Lyn. ⺠PKCθ inhibition reduces CCK- and TPA-stimulation of PKD1, Src, RafC, PYK2, p125FAK and IKKα/β, but not enzyme secretion.
Keywords
PAR4FAKVIP12-O-tetradecanoylphorbol-13-acetatepKaIGF-1CCKGPCRCARMAPLC8-Bromo-cyclic adenosine monophosphate8-br-cAMPPKCIKKIRS-1PKDPYK2HGFPDGFPAR2HRPTCrTGFβCCK-JMV-180bFGFtPAPI3KEGFNFκβIκB kinaseMAPK/ERKPancreatic aciniAktTransforming Growth Factor BetaImmunoprecipitationproline-rich tyrosine kinase 2GastrointestinaldiacylglycerolDAGinsulin receptor substrate 1SignalingCo-IPepidermal growth factorHepatocyte growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorbasic fibroblast growth factorinsulin-like growth factor 1Nuclear factor-kappa Bphospholipase CCo-ImmunoprecipitationHorseradish peroxidaseprotein kinase Aprotein kinase Bprotein kinase Dmitogen-activated protein kinasevasoactive intestinal peptideCblKinasefocal adhesion kinaseprotease-activated receptor 2T-cell receptorG protein-coupled receptor
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Authors
Veronica Sancho, Marc J. Berna, Michelle Thill, R.T. Jensen,