Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8304424 | Biochimie | 2016 | 8 Pages |
Abstract
The severe malfunctioning of the OS aerobic respiratory capacity after 6Â h BL treatment may be the consequence of a self-induced damage. BL exposure would cause an initial over-functioning of both the phototransduction and respiratory chain, with reactive oxygen species production. In a self-renewal vicious cycle, membrane and protein oxidative damage, proton leakage and uncoupling, would impair redox chains, perpetuating the damage and causing hypo-metabolism with eventual apoptosis of the rod. Data may shed new light on the rod-driven retinopathies such as Age Related Macular Degeneration, of which blue-light irradiated retina represents a model.
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Authors
Daniela Calzia, Isabella Panfoli, Nora Heinig, Ulrike Schumann, Marius Ader, Carlo Enrico Traverso, Richard H.W. Funk, Cora Roehlecke,