Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8304574 | Biochimie | 2015 | 45 Pages |
Abstract
The selection constraint of having funneled folding landscapes has left its imprint on the sequences of existing protein structural families. Quantitative analysis of co-evolution patterns allows us to infer the statistical characteristics of the folding landscape. These turn out to be consistent with what has been obtained from laboratory physicochemical folding experiments signaling a beautiful confluence of genomics and chemical physics.
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Authors
Peter G. Wolynes,