Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via the PKC/ERK/c-Fos pathway in RAW264.7 macrophages

Proposed mechanism underlying BA-inhibition of oxidant stress-induced LPL secretion and decrease of cellular lipid accumulation in macraphages. Treatment of RAW264.7 macrophages with BA inhibits intracellular ROS-mediated PKC/ERK/c-Fos signaling pathways, and consequently decreases oxidant stress-induced macrophage LPL secretion and attenuates cellular lipid accumulation. BA, Betulinic acid; LPL, Lipoprotein lipase; ROS, reactive oxygen species; PKC, Protein kinase C; ERK1/2, Extracellular signal-regulated protein kinase1/2; AP-1, Activator protein-1.202