Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8304931 | Biochimie | 2015 | 8 Pages |
Abstract
Translational control is a common mechanism used to regulate gene expression and occur in bacteria to mammals. Typically in translational control, an RNA-binding protein binds to a unique sequence in the mRNA to regulate protein synthesis by the ribosomes. Alternatively, a protein may bind to or modify a translation factor to globally regulate protein synthesis by the cell. Here, we review translational control by the fragile X mental retardation protein (FMRP), the absence of which causes the neurological disease, fragile X syndrome (FXS).
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Authors
Eileen Chen, Simpson Joseph,