| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8304949 | Biochimie | 2015 | 12 Pages |
Abstract
ADP-ribosylation reactions consist of mono-ADP-ribosylation, poly-ADP-ribosylation and cyclic ADP-ribosylation. These reactions play essential roles in many important physiological and pathophysiological events. The types of chemical linkages, the evolutionarily conserved motif within the enzymes to determine the target specificity, stereochemistry of the ADP-ribosylated products, and the chemical reactions taking place among the enzymes and substrates are discussed.
Keywords
Hmginhibitory G-proteinPoly-ADP-ribosylationMono-ADP-ribosylationADP-ribosylationPARPsARTDADP-ribosyltransferaseADP-riboseTransducineEF2NMNCTCnuclear magnetic resonanceNAD+β-nicotinamide adenine dinucleotideSchiff baseNMReukaryotic elongation factor 2nicotinamide mononucleotideARTG-proteinguanine nucleotide binding proteinhigh-mobility-groupGiα
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Authors
Vicky M.-H. Sung,