Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8306050 | Biochimie Open | 2017 | 10 Pages |
Abstract
Voltage-Dependent Anion Channel (VDAC) phosphorylated by c-Jun N-terminal Kinase-3 (JNK3) was incorporated into the bilayer lipid membrane. Single-channel electrophysiological properties of the native and the phosphorylated VDAC were compared. The open probability versus voltage curve of the native VDAC displayed symmetry around the voltage axis, whereas that of the phosphorylated VDAC showed asymmetry. This result indicates that phosphorylation by JNK3 modifies voltage-dependence of VDAC.
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Authors
Rajeev Gupta, Subhendu Ghosh,