| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8308356 | Cellular Signalling | 2018 | 52 Pages |
Abstract
Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipose development and lipid homeostasis. Increasing evidence demonstrated that lncRNAs (long non-coding RNAs), a class of non-protein coding RNAs of >200 nucleotides in length, are identified as key regulators in obesity-related biological processes through diverse regulatory mechanisms. In this review, we concentrate on recent and relevant studies on the roles of lncRNAs in regulation of white adipogenesis, brown adipocyte differentiation and lipid metabolism. In addition, the diagnostic and therapeutic potential of lncRNAs is highlighted, and that will make recommendations for the future application of lncRNAs in the treatment of obesity.
Keywords
lncRNAsBATPRDM16CEBPAABCA1FABP4HnrnpuEbf2HDL-CDNA methyltransferase 1LDL-CDnmt1PTBP1EZH2ACCALXRHSLOx-LDLADSCsPPARGRUNX2FASACSL1heterogeneous nuclear ribonucleoprotein UMarrow mesenchymal stem cellsEpigallocatechin-3-gallateEGCGBMSCsSREBP1cHDACHoxa3HMGCRHFDenhancer of Zeste 2GPR119PGC1a3-hydroxy-3-methylglutaryl coenzyme A reductaseATP-binding cassette transporter A1CCAAT/enhancer binding protein αPLIN2Long non-coding RNAsUcp1apoapolipoproteinacetyl-CoA carboxylase αfatty acid synthaseWhite adipose tissuebrown adipose tissuetriglyceridePR domain containing 16TherapeuticsCompeting endogenous RNAHigh fat dietelectron transport chainceRNARunt-related transcription factor 2hormone-sensitive lipaseLipid metabolismObesityGene ontologyhistone deacetylaseETcfatty acid binding protein 4uncoupling protein 1perilipin 2polPolymeraseWATtotal cholesterolHigh-density lipoprotein-cholesterolLow-density lipoprotein-cholesterolLiver X receptorsperoxisome proliferator-activated receptor γ
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Authors
Chen Chen, Qingming Cui, Xing Zhang, Xuan Luo, Yingying Liu, Jianbo Zuo, Yinglin Peng,