Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8308451 | Cellular Signalling | 2018 | 50 Pages |
Abstract
7-(6-(2-methyl-imidazole))-coumarin could interfere SVCV replication inside or outside of cells through two different approaches. Before the process of virus entry into EPC cells, D5 has an impact on SVCV glycoprotein structure so as to disrupt viral binding to the cell surface or translocation to the cytosol. Another strategy for D5 to against SVCV is that, D5 significantly suppresses SVCV-activated autophagy, which is beneficial for the host cells to restrict SVCV viral replication, accompanied by a higher phosphorylation of Akt-mTOR.196
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Authors
Wei-Chao Chen, Lei Liu, Yu-Feng Shen, Yang Hu, Fei Ling, Gao-Xue Wang, Bin Zhu,