| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8309623 | Clinica Chimica Acta | 2018 | 10 Pages |
Abstract
Forkhead box protein C2 (FOXC2), a transcription factor of the forkhead/winged-helix family, is required for embryonic and prenatal development. FOXC2 acts as a crucial modulator during both angiogenesis and lymphangiogenesis via multiple angiogenic and lymphangiogenic pathways, respectively. Although recent studies have shed light on the emerging role of FOXC2 in cancer, very little is known about the precise underlying mechanisms. The purpose of this review is to summarize the current understanding of FOXC2 and provide potential mechanistic explanations of the relationship between FOXC2 and cancer, as well as discuss the prospect for future research in the promising prognostic value of FOXC2 in cancer.
Keywords
EGFRGLI1HGFOPNBmi-1ZEB1CDDPBMSCGSK3βangiopoietin-2α-MSHTGFβ1PDGFRCAFsERKPI3Kp-GSK-3βCSCsFoxc2shRNAHK2zinc finger E-box binding homeobox 1B lymphoma Mo-MLV insertion region 1 homologSUMOCDK1C/EBPdll4MAPKmtTFAsiRNAAng-2tumor angiogenesisOsteopontintransforming growth factorCell proliferationEMTShhNSCLCNon-small cell lung cancerHey2Bone marrow mesenchymal stem cellCancer stem cellscisplatinsonic hedgehogHepatocyte growth factorVascular Endothelial Growth Factor (VEGF)PhosphatePhosphatidylinositol 3-kinaseCarcinoma-associated fibroblastsLymphangiogenesisshort hairpin alpha melanocyte stimulating hormoneglioma-associated oncogene homolog 1hexokinaseCCAAT/enhancer-binding proteinmitogen-activated protein kinaseplatelet derived growth factor receptorsmall ubiquitin-like modifierextracellular-regulated kinaseEpithelial–mesenchymal transitionEpidermal growth factor receptor
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Authors
Teng Wang, Lei Zheng, Qian Wang, Yan-Wei Hu,