Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8309962 | Clinica Chimica Acta | 2016 | 10 Pages |
Abstract
Steroid receptor RNA activator (SRA) is a type of long noncoding RNA (lncRNA) which coordinates the functions of various transcription factors, enhances steroid receptor-dependent gene expression, and also serves as a distinct scaffold. The novel, profound and expanded roles of SRA are emerging in critical aspects of coactivation of nuclear receptors (NRs). As a nuclear receptor coactivator, SRA can coactivate androgen receptor (AR), estrogen receptor α (ERα), ERβ, progesterone receptor (PR), glucocorticoid receptor (GR), thyroid hormone receptor and retinoic acid receptor (RAR). Although SRA is one of the least well-understood molecules, increasing studies have revealed that SRA plays a key role in both biological processes, such as myogenesis and steroidogenesis, and pathological changes, including obesity, cardiomyopathy, and tumorigenesis. Furthermore, the SRA-related signaling pathways, such as the mitogen-activated protein kinase (p38 MAPK), Notch and tumor necrosis factor α (TNFα) pathways, play critical roles in the pathogenesis of estrogen-dependent breast cancers. In addition, the most recent data demonstrates that SRA expression may serve as a new prognostic marker in patients with ER-positive breast cancer. Thus, elucidating the molecular mechanisms underlying SRA-mediated functions is important to develop proper novel strategies to target SRA in the diagnosis and treatment of human diseases.
Keywords
SRC-1PCOStranscriptional coactivatorSF-1NANOGRARTrxGPRC2CTCFMyoDPKRRRMRBP-JPACTTRBPSteroid receptor RNA activatorHairy and enhancer of split-1HP1γDdx5SLIRPJnklncRNAPPARγTNFαSTRERαAF-2SRAPC/EBPαc-Jun N-terminal kinasesp38 MAPKRNA recognition motiflong noncoding RNAsactivation function-2myogenic differentiation 1tumor necrosis factor αSharpSraStem-loop structurePolycystic ovary syndromeLong noncoding RNACCCTC-binding factorSteroidogenic factor 1Hes1mitogen-activated protein kinasepolycomb repressive complex 2Peroxisome proliferator-activated receptor gammatrithorax groupAndrogen Receptorsteroid receptor coactivator-1Estrogen receptor αRetinoic acid receptorProgesterone receptorglucocorticoid receptorNuclear receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Chan Liu, Hong-Tao Wu, Neng Zhu, Ya-Ning Shi, Zheng Liu, Bao-Xue Ao, Duan-Fang Liao, Xi-Long Zheng, Li Qin,