Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8310064 | Clinica Chimica Acta | 2016 | 10 Pages |
Abstract
Here we will discuss recent progress in high-throughput laboratory methods for glycomics (i.e. the study of glycan structures) and glycoprotein quantification by methods such as mass spectrometry and nuclear magnetic resonance spectroscopy. We will also review the clinical utility of glycoprotein and glycan measurements in the prediction of common low-grade inflammatory disorders including cardiovascular disease, diabetes and cancer, as well as for monitoring autoimmune disease activity.
Keywords
CDGHOMA-IRUPLCGlcNAcDAS28LDL-CPSAESRIgG2-ABWHSPREVENDT2DMAGPhsCRPsLeASAANAFLDCeAHCCα-fetoproteinα1-Acid glycoproteinRheumatoid arthritiscarcinoembryonic antigenProstate specific antigenCongenital disorders of glycosylationHomeostatic model assessment of insulin resistanceNon-alcoholic steatohepatitisinflammationimmunoglobulin Gcardiovascular diseasenon-alcoholic fatty liver diseaseBiomarkerAFPEnzyme-linked immunosorbent assayELISANMRType 2 diabetes mellitusCVDerythrocyte sedimentation rateserum amyloid Abody mass indexBMIMass spectrometryNuclear magnetic resonance spectroscopySystemic lupus erythematosusSLEJUPITERGenome-wide association studiesWomen's Health StudyGWASNash N-acetylglucosamineHepatocarcinomaHILIChigh-sensitivity C-reactive proteinC-reactive proteinCRPhigh performance liquid chromatographyUltraperformance liquid chromatographyhydrophilic interaction liquid chromatographyHPLClow density lipoprotein cholesterolGlycanGlycosylationGlycomicsglycoproteins
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Authors
Margery A. Connelly, Eke G. Gruppen, James D. Otvos, Robin P.F. Dullaart,