Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8310308 | Clinica Chimica Acta | 2016 | 23 Pages |
Abstract
Vitamin D is a fat-soluble vitamin that belongs to the family of steroid hormones. The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR). VDR is a transcription factor located in the nuclei of target cells that mediates the genomic action of the active form of vitamin D (1,25(OH)2D3). This transcription factor is distributed in various tissues, including the reproductive system. The presence of VDR in female reproductive tissue suggests that vitamin D is involved in female reproduction. The present article reviews the impact of vitamin D on anti-Müllerian hormone (AMH), as an ovarian reserve marker, and ovarian steroidogenesis. This article also discusses the impact of vitamin D as a factor that influences infertility and the outcome of in vitro fertilization (IVF), insulin resistance (IR), hyperandrogenism, endometriosis and polycystic ovary syndrome (PCOS).
Keywords
vitamin D response elementsVDREVDRVDBPPCOSclinical pregnancy ratespTHWHRRAGEDHEASRXR17β-HSDSHBGdehydroepiandrosteroneFAIAGEsHOMA-IRretinoid X-receptorROSAMHFemale reproductionAssisted reproductive technologygranulosa cellsPolycystic ovary syndromefree androgen indexbody mass indexBMIIn vitro fertilizationIVFadvanced glycation end-productsInsulin resistanceARTAnti-Müllerian hormonefollicle stimulating hormonesex hormone binding globulinFSHparathyroid hormoneVitamin DVitamin D-binding proteinCRPwaist-hip ratioReactive oxygen speciesreceptor for AGEVitamin D receptor
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Authors
Seyedeh Zahra Shahrokhi, Firouzeh Ghaffari, Faranak Kazerouni,