Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8310320 | Clinica Chimica Acta | 2016 | 51 Pages |
Abstract
The adequate absorption of lipids is essential for all mammalian species due to their inability to synthesize some essential fatty acids and fat-soluble vitamins. Chylomicrons (CMs) are large, triglyceride-rich lipoproteins that are produced in intestinal enterocytes in response to fat ingestion, which function to transport the ingested lipids to different tissues. In addition to the contribution of CMs to postprandial lipemia, their remnants, the degradation products following lipolysis by lipoprotein lipase, are linked to cardiovascular disease. In this review, we will focus on the structure-function and metabolism of CMs. Second, we will analyze the impact of gene defects reported to affect CM metabolism and, also, the role of CMs in other pathologies, such as atherothrombotic cardiovascular disease and diabetes mellitus. Third, we will provide an overview of the laboratory tests currently used to study CM disorders, and, finally, we will highlight current treatments in diseases affecting CMs.
Keywords
TRLPPAR-Alphacoat protein complex IIHSPGTRLSSR-BIMGATVLDLDGATANGPTL4Diglyceride acyltransferaseSORT1MTTPabetalipoproteinemiaFABPGPIHBP1NPC1L1chylomicronPUFAsLipase maturation factor 1Niemann–Pick C1-Like 1LRPHDLGlycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1LMF1ANGPTL8LDLRACATCMSGLP-1ANGPTL3VLDLRAtherosclerosislaboratory testingperoxisome proliferator-activated receptor alphaAngiopoietin-like protein 3apoapolipoproteinPolyunsaturated fatty acidsEnterocytetriglycerideTherapytriglyceride-rich lipoproteintriglyceride-rich lipoproteinsLDLHigh-density lipoproteinsvery low-density lipoproteinslow-density lipoproteinsHeparan sulfate proteoglycanHypobetalipoproteinemiaPCV یا Pneumococcal conjugate vaccineFatty acid binding proteinmicrosomal triglyceride transfer proteinangiopoietin-like protein 4Angiopoietin-like protein 8LDL receptor-related proteinglucagon-like peptide-1chylomicronsCOPIILDL receptorVLDL receptorscavenger receptor class B type 1
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Authors
Josep Julve, Jesús M. MartÃn-Campos, Joan Carles Escolà -Gil, Francisco Blanco-Vaca,