| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8310938 | Clinica Chimica Acta | 2015 | 6 Pages |
Abstract
CYP3A5*3 increased the blood exposure of tacrolimus through its metabolic reduction. ABCB1 C3435T led to a higher blood exposure of tacrolimus and its major metabolite. The ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affected renal function in rheumatoid arthritis patients.
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Authors
Takafumi Naito, Yasuaki Mino, Yuki Aoki, Kumi Hirano, Kumiko Shimoyama, Noriyoshi Ogawa, Yoshiyuki Kagawa, Junichi Kawakami,