Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8310949 | Clinica Chimica Acta | 2015 | 9 Pages |
Abstract
Osteosarcoma (OS) is a primary malignant bone tumor with high morbidity that principally emerges in children and adolescents. Presently, the prognosis of OS patients remains poor due to resistance to chemotherapy, highlighting the need for new therapeutic approaches. MicroRNAs (miRNAs), a class of small noncoding RNA molecules, can negatively modulate protein expression at the post-transcriptional level. miRNAs regulate a variety of normal physiologic processes and are involved in tumorigenesis and development of multiple malignancies, including OS. Some miRNAs are differentially expressed in OS tissues, cell lines and serum, and have been shown to correlate with the malignant phenotype and prognosis. These altered miRNAs function as oncogenes or tumor suppressor genes in this process. Moreover, restoration of miRNA expression has shown promise for the treatment of OS. Here, we describe miRNA biochemistry with a focus on expression profile, role and therapeutic potential in OS. A better understanding will facilitate the identification and characterization of novel biomarkers and development of miRNA-targeted therapies.
Keywords
DATSRNA polmiRNA recognition elementsExportin 5HSP90B1LZTS1APE1MREsMDMTP53DGCR8diallyl trisulfideHMGB1BMP2IGF1RPI3KLNAMMPmiRNAsCSCsmTORFAKapurinic/apyrimidinic endonuclease 1RNA polymeraseArgonauteOsteosarcomaLocked Nucleic Acidfatty acid synthasehigh-mobility group box 1RISCMurine double minutemicroRNAsTumor suppressor p53Cancer stem cellsFasnphosphatase and tensin homolog deleted on chromosome tenphosphatidylinositol-3-kinasematrix metalloproteinaseRNA-Induced Silencing ComplexNotchmammalian target of rapamycinbone morphogenetic protein 2AGOPtenChemoresistanceinsulin-like growth factor 1 receptor
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Authors
Jian Zhang, Yi-Guo Yan, Cheng Wang, Shu-Jun Zhang, Xiao-Hua Yu, Wen-Jun Wang,