| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8311345 | Clinica Chimica Acta | 2015 | 7 Pages |
Abstract
Drug confirmation by mass spectrometry coupled with chromatography is essential to toxicology, doping control, pain management, and workplace drug testing. High confidence in this technology is due to its superior specificity and sensitivity. However, there are challenges associated with drug confirmation, and proper setup and validation of these assays are important in assuring high-quality results. In this article, assay parameters required for drug confirmation are summarized based on recent scientific publications, various established guidelines, and our own practical experience. Factors affecting the result quality and correct results interpretation are critically reviewed. Several emerging technologies and their potential applications are briefly explored.
Keywords
CLSIAPIAPCIppmLLEMRMFWHMHRMSRRTLIMSSOFTQMSESILLOQ6-Monoacetylmorphine6-MAMm/zinternal standardLiquid-liquid extractionmatrix-assisted laser desorption/ionizationlower limit of quantificationLLODRetention timeRelative retention timeSAMHSASubstance Abuse and Mental Health Services AdministrationLaboratory Information Management SystemSIMQuadrupole mass spectrometryMass spectrometryhigh-resolution mass spectrometryfull-width at half-maximumInternal Diameterparts per millionMALDIlower limit of detectionClinical and Laboratory Standards InstituteMass-to-charge ratioselected ion monitoringmultiple reaction monitoringCollege of American Pathologistsliquid chromatographyhigh-performance liquid chromatographyHPLCGas chromatographyCaPquality controlelectrospray ionizationelectron ionizationchemical ionizationatmospheric pressure chemical ionizationAtmospheric pressure ionization
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Authors
Chao Yuan, Derrick Chen, Sihe Wang,