Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8311416 | Clinica Chimica Acta | 2014 | 14 Pages |
Abstract
Environmental stresses threatening cell homeostasis trigger various cellular responses ranging from the activation of survival pathways to eliciting programmed cell death. Cellular stress response highly depends on the nature and level of the insult as well as the cell type. Notably, the interplay among all these responses will ultimately determine the fate of the stressed cell. Human DExD/H RNA helicases are ubiquitous molecular motors rearranging RNA secondary structure in an ATP-dependent fashion. These highly conserved enzymes participate in nearly all aspects of cellular process involving RNA metabolism. Although numerous functions of DExD/H RNA helicases are well documented, their importance in stress response is only just becoming evident. This review outlines our current knowledge on major mechanistic themes of human DExD/H RNA helicases in response to stressful stimuli, especially on emerging molecular models for the functional roles of these enzymes in the stress survival regulation.
Keywords
MYD88PDCmTORRNPRhoANF-kBCTDAMDFCCPODNoligodeoxynucleotidePAMPIKKCCCPG3BP1TRAF2uPANLRP3IRFIRESVSVVACVTBK1Crm1MDA5RNA helicase ARIGmDCsRLRTRAF3RACK1uORFROCK1LGP2RHARepressor domainRecACDNIPS-1MBNL1Nucleic acid sensingKSRPPABPARE-BPTNF receptor-associated factor 3Cyclic dinucleotideWDR62Rho-associated, coiled-coil containing protein kinase 1IFNBUSP10stimulator of IFN geneseIFIκB kinaseROSTRIFlaboratory of genetics and physiology 2pathogen-associated molecular patterninterferonIFNTIR-domain-containing adapter-inducing interferon-βinterleukinProcessing bodyTerminal deoxynucleotidyl transferase dUTP nick end labelingTUNELSingle strandedTIRRISCC-terminal domainDouble strandedribonucleoproteininternal ribosome entry siteplasmacytoid dendritic cellsmyeloid dendritic cellsendoplasmic reticulumTAPinterferon regulatory factorTNF receptor-associated factor 2Ras homolog gene family member AAU-rich elementEukaryotic Initiation FactorSuperfamilyVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nuclear factor kappa-light-chain-enhancer of activated B cellsupstream open reading framecaspase activation and recruitment domainurokinase-type plasminogen activatorRNA-Induced Silencing ComplexCell deathUTR یا untranslated regions untranslated regionSTINGmammalian target of rapamycinAREHCVHepatitis C virusVesicular stomatitis virusHIVhuman immunodeficiency virusvaccinia virusmyeloid differentiation primary response gene 88Stress responsePoly(A) binding proteinpoly(I:C)Polyinosinic–polycytidylic acidretinoic acid-inducible gene 1CARDCarbonyl cyanide-4-(trifluoromethoxy)phenylhydrazonecarbonyl cyanide m-chlorophenyl hydrazoneStress granuleReactive oxygen speciesRIG-I-like receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Jing-Wen Shih, Yan-Hwa Wu Lee,