| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8313775 | Clinica Chimica Acta | 2013 | 5 Pages |
Abstract
⺠We enrolled 46 immunocompromised patients taking an oral solution of ITZ. ⺠Pharmacokinetics of ITZ, OH-ITZ, and keto-ITZ were evaluated. ⺠The plasma concentration of OH-ITZ was strongly correlated with that of ITZ. ⺠Metabolism of OH-ITZ to keto-ITZ was saturable and variable in clinical settings. ⺠Plasma concentrations of ITZ and OH-ITZ were associated with Alb, TB, and eGFR.
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Authors
Yasuaki Mino, Takafumi Naito, Takayuki Watanabe, Takahiro Yamada, Tatsuya Yagi, Hiroshi Yamada, Junichi Kawakami,