| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8313983 | Clinica Chimica Acta | 2012 | 8 Pages |
Abstract
⺠Cleavage of APP by β-secretase is the rate limiting step in the generation of Aβ. ⺠Targeting BACE1 gains a considerable significance on AD research. ⺠Data regarding BACE1 and their significance as a potential target in AD pathology
Keywords
APPTGNVGSCβ-site APP cleaving enzyme 1CTFNRGGPiAICDAβBACE1HTSTSAKPIAPLPGGARNA interferenceRNAiβ-AmyloidADAMTransition state analogApoeapolipoprotein Emild cognitive impairmentFADAlzheimer's diseaseSporadic Alzheimer's diseasefamilial Alzheimer's diseaseNeurodegenerative diseaseTransgenicAmyloid precursor protein intracellular domainTrans Golgi Networkendoplasmic reticulumhigh throughput screeningSADCSFCerebrospinal fluidKunitz protease inhibitorNeuregulinMCIPresenilinamyloid precursor proteinamyloid precursor-like proteinamyloid-β peptidevoltage-gated sodium channelglycosylphosphatidylinositol
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Authors
M. Sathya, P. Premkumar, C. Karthick, P. Moorthi, K.S. Jayachandran, M. Anusuyadevi,