Biologic variability of C-reactive protein: Is the available information reliable?

► The knowledge of biologic variability of CRP is crucial. ► We systematically reviewed eleven publications on CRP biologic variation. ► Almost all were limited by choice of assay, protocol application and statistical analysis. ► The only study that fulfilled all requirements derived components from logarithmically transformed data. ► There is an obvious lack of robust data on biologic variability of CRP.