Toll-like receptors and macrophage activation in atherosclerosis

Article ID	Journal	Published Year	Pages	File Type
8315324	Clinica Chimica Acta	2012	12 Pages	PDF

Abstract

âº Innate immune responses are prominent in the pathogenesis of atherosclerosis. âº Many Toll-like receptors (TLRs) are increased in atherosclerosis. âº Innate immune cells, especially macrophages, associate with plaque vulnerability. âº TLR stimulation may promote inflammatory macrophages in atherosclerosis. âº TLRs serve as a potentially strong therapeutic target against atherosclerosis.

Keywords

MDC LDC RIG-I M-CSF HSs LSS VCAM-1 MDA5 NLR CLR PRR GM-CSF TLR PAMP RLR DAMP TCFA CDC SMC MMP LGP2 thin-cap fibroatheroma Atherosclerosis laboratory of genetics and physiology 2 Oscillatory shear stress damage associated molecular pattern OSS Innate immunity low shear stress Toll-like receptor Dendritic cell Smooth muscle cell conventional dendritic cell Myeloid dendritic cell Cell signalling granulocyte-macrophage colony-stimulating factor macrophage colony stimulating factor low density lipoprotein LDL matrix metalloproteinase Macrophages vascular cell adhesion molecule-1 Monocytes pathogen associated molecular pattern melanoma differentiation-associated gene 5 retinoic acid-inducible gene-I Nod-like receptor RIG-I-like receptor pattern recognition receptor C-type lectin receptor