| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8315364 | Clinica Chimica Acta | 2012 | 7 Pages |
Abstract
⺠Monitoring minimal residual disease (MRD) is useful to evaluate therapy for leukemia. ⺠MRD assay is based on quantitative polymerase chain reaction (PCR) analysis. ⺠Fusion genes and rearranged Ig/TCR genes have been used as MRD markers. ⺠PCR-based procedures for detecting single nucleotide mutations have been proposed. ⺠Single nucleotide mutations can be used as potential MRD markers.
Keywords
qPCRCN-AMLSTR-PCRCOLD-PCRAMLMRDHSCTARMSMFCPNALNATCrLocked nucleic acidsPeptide nucleic acidsimmunoglobulin amplification refractory mutation systemMinimal residual diseaseMultiparameter flow cytometryAcute myelogenous leukemiaAcute lymphoblastic leukemiaMamaALLquantitative polymerase chain reactionHematopoietic stem cell transplantationT-cell receptor
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Authors
Kazuyuki Matsuda, Mitsutoshi Sugano, Takayuki Honda,