Article ID Journal Published Year Pages File Type
8315833 Clinica Chimica Acta 2011 5 Pages PDF
Abstract
► We compared the copy number of CCL3L1 gene in control and asthma subjects. ► Mean copy number was significantly lower in asthma than control subjects. ► Low copy number of ≤ 1 was associated with higher asthma risk and serum IgE level. ► High copy number of ≥ 5 was associated with decreased asthma risk. ► CCL3L1 protein up-regulated IL-10 expression in house dust mite-stimulated monocytes.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Copy number variation of CCL3L1 influences asthma risk by modulating IL-10 expression
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