| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8316298 | Clinica Chimica Acta | 2011 | 10 Pages |
Abstract
The time course of the observed modifications indicated that the pattern of glycation products changed as HSA was incubated over longer periods of time with glucose. Several regions found to have significant levels of modification were at or near the major drug binding regions on HSA. These results explain why the interaction of some drugs with HSA has been observed to vary with the level of glycation for this protein.
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Biochemistry
Authors
Omar S. Barnaby, Ronald L. Cerny, William Clarke, David S. Hage,