Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8316558 | Clinica Chimica Acta | 2011 | 12 Pages |
Abstract
N-acetyl-l-leucine is an endogenous compound included in all biological specimens (plasma, hair, liver and kidney). Therefore, this metabolite appears to be a potential biomarker candidate related to diabetes. Although the structures of other biomarker candidates have still not yet determined, the present approach based upon a metabolite profiling study using UPLC-ESI-TOF-MS could be helpful for understanding the abnormal state of various diseases.
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Authors
Haruhito Tsutsui, Toshio Maeda, Jun Zhe Min, Shinsuke Inagaki, Tatsuya Higashi, Yoshiyuki Kagawa, Toshimasa Toyo'oka,