| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8317914 | Clinical Biochemistry | 2012 | 6 Pages |
Abstract
⺠Paget's disease is a focal bone disorder characterised by accelerated remodelling activity. ⺠Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity, but there is an important genetic predisposition. ⺠All bone turnover markers (except osteocalcin) are increased in patients with active disease; of the newer markers plasma procollagen-1 N-peptide performs best. ⺠Treatment with potent bisphosphonates such as zoledronate can achieve long-term remission. ⺠Good suppression of turnover markers early after treatment predicts the duration of remission.
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Authors
Tim Cundy, Ian R. Reid,