Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319410 | Current Opinion in Structural Biology | 2018 | 7 Pages |
Abstract
Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. Although being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.
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Authors
Hendrik Szurmant, Martin Weigt,