Article ID Journal Published Year Pages File Type
8319414 Current Opinion in Structural Biology 2018 9 Pages PDF
Abstract
This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
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