Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319451 | Current Opinion in Structural Biology | 2018 | 9 Pages |
Abstract
Biomolecular structure determination has long relied on heuristics based on physical insight; however, recent efforts to model conformational ensembles and to make sense of sparse, ambiguous, and noisy data have revealed the value of detailed, quantitative physical models in structure determination. We review these two key challenges, describe different approaches to physical modeling in structure determination, and illustrate several successes and emerging technologies enabled by physical modeling.
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Authors
Kari Gaalswyk, Mir Ishruna Muniyat, Justin L MacCallum,