Revisiting supersaturation as a factor determining amyloid fibrillation

- Amyloid fibrils are formed by a nucleation-growth mechanism.
- Formation of amyloid fibrils is similar to the crystallization of solutes.
- Solubility and supersaturation are important factors of amyloid fibrillation.
- Amyloid fibrillation competes with amorphous aggregation.
- Formation of distinct aggregates was explained by a competition mechanism.