Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319792 | Current Opinion in Structural Biology | 2016 | 10 Pages |
Abstract
The eukaryotic genome is hierarchically packaged into chromatin in the nucleus. The organization and dynamics of 30-nm chromatin fibers, which is typically regarded as the secondary structure of chromatin, play a crucial role in regulating DNA accessibility for gene expression. Here we reviewed some recent progresses on the structural studies on nucleosomes, nucleosome-protein complexes, and chromatin fibers, focusing on the structural insights how the chromatin structure is regulated by different epigenetic regulation factors.
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Authors
Ping Zhu, Guohong Li,