Article ID Journal Published Year Pages File Type
8319792 Current Opinion in Structural Biology 2016 10 Pages PDF
Abstract
The eukaryotic genome is hierarchically packaged into chromatin in the nucleus. The organization and dynamics of 30-nm chromatin fibers, which is typically regarded as the secondary structure of chromatin, play a crucial role in regulating DNA accessibility for gene expression. Here we reviewed some recent progresses on the structural studies on nucleosomes, nucleosome-protein complexes, and chromatin fibers, focusing on the structural insights how the chromatin structure is regulated by different epigenetic regulation factors.
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