Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319796 | Current Opinion in Structural Biology | 2016 | 11 Pages |
Abstract
- Traditional aptamers fold into structures with established nucleic acid motifs.
- Modified nucleotides expand the repertoire of known nucleic acid structural motifs.
- Hydrophobic modifications make essential inter-molecular and intramolecular interactions.
- The flexible phosphodiester bond of aptamers allows for high shape complementarity.
- In most cases, aptamer binding occurs without a conformational change of the target.
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Authors
Amy D Gelinas, Douglas R Davies, Nebojsa Janjic,