Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319799 | Current Opinion in Structural Biology | 2016 | 9 Pages |
Abstract
Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5â², including the 5â² cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5â² RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.
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Authors
Daisy W Leung, Gaya K Amarasinghe,