| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8319825 | Current Opinion in Structural Biology | 2015 | 9 Pages |
Abstract
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
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Authors
Vahe Bandarian, Catherine L Drennan,