Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319900 | Current Opinion in Structural Biology | 2015 | 12 Pages |
Abstract
- Fluorescence is a recent addition to the mass spectrometry-enabled technical toolbox.
- Selectivity provided by MS enables dissection of complex intermolecular interactions.
- FRET of mass-selected de-solvated biomolecules provides nm-range distance constraints.
- Dynamic quenching measurements assess conformational fluctuations.
- These tools provide insight into intrinsic protein structure, stability and dynamics.
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Authors
Martin F Czar, Rebecca A Jockusch,