Methyl-specific isotopic labeling: a molecular tool box for solution NMR studies of large proteins

- Methyl-specific labeling for solution NMR studies of proteins above 100 kDa.
- Specific labeling of any combination of methyl groups in protein overexpressed in E. coli.
- Detection of NOEs between remote CH3 probes in membrane proteins and large complexes.
- Dynamics, interaction and mechanistic investigations of protein machineries.