Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319946 | Current Opinion in Structural Biology | 2015 | 7 Pages |
Abstract
- Missense mutations frequently alter protein biophysical characteristics such as stability, dynamics and interactions.
- Protein biophysical properties are interrelated and diseases often result from simultaneous changes of several properties.
- Magnitude and direction of the change cannot be directly implicated to the phenotype and disease risk.
- Disease-causing mutations tend to cause large changes in the physico-chemical properties of the mutation site.
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Authors
Tugba G Kucukkal, Marharyta Petukh, Lin Li, Emil Alexov,