Article ID Journal Published Year Pages File Type
8319946 Current Opinion in Structural Biology 2015 7 Pages PDF
Abstract

- Missense mutations frequently alter protein biophysical characteristics such as stability, dynamics and interactions.
- Protein biophysical properties are interrelated and diseases often result from simultaneous changes of several properties.
- Magnitude and direction of the change cannot be directly implicated to the phenotype and disease risk.
- Disease-causing mutations tend to cause large changes in the physico-chemical properties of the mutation site.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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