Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319959 | Current Opinion in Structural Biology | 2015 | 11 Pages |
Abstract
Intrinsically disordered proteins (IDPs) showcase the importance of conformational plasticity and heterogeneity in protein function. We summarize recent advances that connect information encoded in IDP sequences to their conformational properties and functions. We focus on insights obtained through a combination of atomistic simulations and biophysical measurements that are synthesized into a coherent framework using polymer physics theories.
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Authors
Rahul K Das, Kiersten M Ruff, Rohit V Pappu,