Article ID Journal Published Year Pages File Type
8319989 Current Opinion in Structural Biology 2015 7 Pages PDF
Abstract

- We review recent drugs mainly targeting Aβ and how they were identified.
- We report their results from in vitro and in vivo experiments and clinical trials.
- We describe simulation results on how inhibitors interact with Aβ species.
- Macromolecular crowding should be treated in simulations.
- How Aβ mutations at residue 2 protect from Alzheimer remains unknown.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
, ,