Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8319989 | Current Opinion in Structural Biology | 2015 | 7 Pages |
Abstract
- We review recent drugs mainly targeting Aβ and how they were identified.
- We report their results from in vitro and in vivo experiments and clinical trials.
- We describe simulation results on how inhibitors interact with Aβ species.
- Macromolecular crowding should be treated in simulations.
- How Aβ mutations at residue 2 protect from Alzheimer remains unknown.
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Authors
Andrew J Doig, Philippe Derreumaux,