Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8320021 | Current Opinion in Structural Biology | 2015 | 13 Pages |
Abstract
Riboswitches are structured regions of mRNAs that modulate gene expression in response to specific binding of low molecular-weight ligands. They function by induced transitions between different functional conformations. The standard model assumed that the two functional states, the ligand-bound and ligand-free state, populated only two stable conformations. Recent discoveries of multiple conformations for the apo-state and holo-state of riboswitches challenge this model. Moreover, it becomes evident that detected conformational heterogeneity - mostly in the apo-state - provides sensitivity to multiple environmental inputs for riboswitch-based gene-regulation.
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Authors
Boris Fürtig, Senada Nozinovic, Anke Reining, Harald Schwalbe,