| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8320115 | Current Opinion in Structural Biology | 2014 | 8 Pages |
Abstract
In this review we discuss the current advances relating to structure determination from protein microcrystals with special emphasis on the newly developed method called MicroED. This method uses a transmission electron cryo-microscope to collect electron diffraction data from extremely small 3-dimensional (3D) crystals. MicroED has been used to solve the 3D structure of the model protein lysozyme to 2.9Â Ã
resolution. As the method further matures, MicroED promises to offer a unique and widely applicable approach to protein crystallography using nanocrystals.
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Authors
Brent L Nannenga, Tamir Gonen,