Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8320171 | Current Opinion in Structural Biology | 2014 | 10 Pages |
Abstract
The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
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Authors
Sergio Martinez Cuesta, Nicholas Furnham, Syed Asad Rahman, Ian Sillitoe, Janet M Thornton,