| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8320201 | Current Opinion in Structural Biology | 2014 | 7 Pages |
Abstract
- UCS proteins comprise a diverse family of myosin chaperones.
- UCS chaperones differ in their substrate targeting, folding and activation mechanism.
- TPR-less UCS chaperones dimerize to control the myosin-actin interaction.
- TPR-containing UCS proteins compose multimeric assembly lines for myofilaments.
- Misregulation of UCS activity is linked to myopathies including heart diseases.
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Authors
Doris Hellerschmied, Tim Clausen,